study on the effect of paliurus spina-christi on cholesterol, triglyceride and hdl levels in diabetic male rats fed a high cholesterol diet

paliurus spina-christi mill (rhamnaceae) has been used in folk medicine as a hypocholesterolemic agent. in this study, the effect of total fruit extract on lowering lipid content of serum was investigated. male rats were introduced streptozocin, subsequently fed with a high cholesterol diet and concomitantly treated with various doses of the extract. after 8 days, serum levels of cholesterol, triglyceride and hdl were measured. it was found that the administration of 100 mg/kg/day of the extract had reduced the amount of total cholesterol by 45.5% and the administration of 50 mg/kg/day reduced the amount of triglyceride by 48.73%. no significant enhancement was found in the amount of hdl. it was concluded that of paliurus spina-christi extract can inhibit the enhancement of cholesterol and triglyceride.